抗 XIAP 磁珠
02AB00105
E3 ubiquitin-protein ligase XIAP (X-linked inhibitor of apoptosis protein) is a crucial member of the inhibitor of apoptosis (IAP) family, primarily functioning to inhibit programmed cell death by binding to and inhibiting caspases-3, -7, and -9. This protein contains three baculoviral IAP repeat (BIR) domains that facilitate its interaction with these caspases, thereby preventing apoptosis and promoting cell survival. XIAP also possesses a RING domain that provides E3 ubiquitin ligase activity, allowing it to ubiquitinate target proteins, which can influence various cellular processes beyond apoptosis, including inflammation and immune responses. Dysregulation of XIAP has been implicated in several diseases, particularly cancer, where its overexpression is associated with tumor progression and resistance to chemotherapy. Additionally, mutations in the XIAP gene are linked to X-linked lymphoproliferative disease, characterized by immune dysregulation and increased susceptibility to infections.
| 规格 | 起售价 |
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技术参数
- 宿主
- Mouse
- 靶点基因名
- XIAP
- 基因别名
- API3; BIRC4; IAP3
- 蛋白别名
- X-linked inhibitor of apoptosis; XIAP
- UniProt
- P98170
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- XIAP
- 蛋白名称
- X-linked inhibitor of apoptosis
- 蛋白别名
- E3 ubiquitin-protein ligase XIAP; Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; RING-type E3 ubiquitin transferase XIAP; X-linked inhibitor of apoptosis protein; X-linked IAP
- 靶点基因名
- XIAP
- 基因别名
- API3; BIRC4; IAP3
- UniProt
- P98170
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG2b
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
E3 ubiquitin-protein ligase XIAP (X-linked inhibitor of apoptosis protein) is a crucial member of the inhibitor of apoptosis (IAP) family, primarily functioning to inhibit programmed cell death by binding to and inhibiting caspases-3, -7, and -9. This protein contains three baculoviral IAP repeat (BIR) domains that facilitate its interaction with these caspases, thereby preventing apoptosis and promoting cell survival. XIAP also possesses a RING domain that provides E3 ubiquitin ligase activity, allowing it to ubiquitinate target proteins, which can influence various cellular processes beyond apoptosis, including inflammation and immune responses. Dysregulation of XIAP has been implicated in several diseases, particularly cancer, where its overexpression is associated with tumor progression and resistance to chemotherapy. Additionally, mutations in the XIAP gene are linked to X-linked lymphoproliferative disease, characterized by immune dysregulation and increased susceptibility to infections.