抗 WWP2 磁珠
02AB00103
WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2) is an E3 ubiquitin ligase that plays a crucial role in various biological processes, including protein ubiquitination, chondrogenesis, and oncogenic signaling pathways. It interacts with Smad proteins and the tumor suppressor PTEN, influencing cell signaling and differentiation. WWP2 has been linked to several diseases, including Spondyloepiphyseal Dysplasia, Nishimura Type, and Cowden Syndrome 1, and its dysregulation can contribute to fibrosis, inflammation, and cancer progression. The inhibition of WWP2 has been identified as a potential therapeutic strategy for treating diseases characterized by fibrosis and inflammation, as it regulates the expression of pro-inflammatory factors and fibroblast activation. Additionally, WWP2 isoforms have distinct functions, with WWP2-N potentially suppressing TGFβ-induced epithelial-to-mesenchymal transition (EMT) and WWP2-C interacting with inhibitory Smad7.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 宿主
- Mouse
- 靶点基因名
- WWP2
- 蛋白别名
- WW domain containing E3 ubiquitin protein ligase 2; WWP2
- UniProt
- O00308
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- WWP2
- 蛋白名称
- WW domain containing E3 ubiquitin protein ligase 2
- 蛋白别名
- NEDD4-like E3 ubiquitin-protein ligase WWP2; Atrophin-1-interacting protein 2; AIP2; HECT-type E3 ubiquitin transferase WWP2; WW domain-containing protein 2
- 靶点基因名
- WWP2
- UniProt
- O00308
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG2a
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
TAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYE
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2) is an E3 ubiquitin ligase that plays a crucial role in various biological processes, including protein ubiquitination, chondrogenesis, and oncogenic signaling pathways. It interacts with Smad proteins and the tumor suppressor PTEN, influencing cell signaling and differentiation. WWP2 has been linked to several diseases, including Spondyloepiphyseal Dysplasia, Nishimura Type, and Cowden Syndrome 1, and its dysregulation can contribute to fibrosis, inflammation, and cancer progression. The inhibition of WWP2 has been identified as a potential therapeutic strategy for treating diseases characterized by fibrosis and inflammation, as it regulates the expression of pro-inflammatory factors and fibroblast activation. Additionally, WWP2 isoforms have distinct functions, with WWP2-N potentially suppressing TGFβ-induced epithelial-to-mesenchymal transition (EMT) and WWP2-C interacting with inhibitory Smad7.