抗 UHRF2 磁珠
02AB00129
E3 ubiquitin-protein ligase UHRF2 (UHRF2) is a critical regulator of cell cycle progression, genomic stability, and epigenetic modifications. It contains several functional domains, including a ubiquitin-like domain and a PHD finger, which facilitate its role in recognizing and binding to methylated DNA and histones, particularly at lysine 9 of histone H3. UHRF2 is involved in the ubiquitination of various substrates, including the acetyltransferase TIP60, thereby influencing DNA repair and chromatin remodeling. Dysregulation of UHRF2 has been implicated in several diseases, particularly in cancer, where it may contribute to tumorigenesis by promoting genomic instability and aberrant epigenetic regulation. For instance, UHRF2 overexpression has been observed in various cancers, including breast and colorectal cancers, suggesting its potential as a biomarker for cancer progression. Additionally, UHRF2's involvement in cell cycle regulation links it to disorders characterized by uncontrolled cell proliferation.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- UHRF2
- 基因别名
- NIRF; RNF107
- 蛋白别名
- ubiquitin like with PHD and ring finger domains 2; UHRF2
- UniProt
- Q96PU4
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- UHRF2
- 蛋白名称
- ubiquitin like with PHD and ring finger domains 2
- 蛋白别名
- E3 ubiquitin-protein ligase UHRF2; Np95/ICBP90-like RING finger protein; Np95-like RING finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF2; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-containing PHD and RING finger domains protein 2
- 靶点基因名
- UHRF2
- 基因别名
- NIRF; RNF107
- UniProt
- Q96PU4
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
PSTSARARLIDPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCP
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
E3 ubiquitin-protein ligase UHRF2 (UHRF2) is a critical regulator of cell cycle progression, genomic stability, and epigenetic modifications. It contains several functional domains, including a ubiquitin-like domain and a PHD finger, which facilitate its role in recognizing and binding to methylated DNA and histones, particularly at lysine 9 of histone H3. UHRF2 is involved in the ubiquitination of various substrates, including the acetyltransferase TIP60, thereby influencing DNA repair and chromatin remodeling. Dysregulation of UHRF2 has been implicated in several diseases, particularly in cancer, where it may contribute to tumorigenesis by promoting genomic instability and aberrant epigenetic regulation. For instance, UHRF2 overexpression has been observed in various cancers, including breast and colorectal cancers, suggesting its potential as a biomarker for cancer progression. Additionally, UHRF2's involvement in cell cycle regulation links it to disorders characterized by uncontrolled cell proliferation.