抗 UBR7 磁珠
02AB00092
UBR7 is a member of the UBR family of E3 ubiquitin ligases that plays important roles in various cellular processes and disease states. It functions as an H2BK120 monoubiquitin ligase and acts as a tumor suppressor in triple-negative breast cancer. UBR7 has been implicated in a neurodevelopmental syndrome characterized by intellectual disability, epilepsy, ptosis, hypothyroidism, and genital anomalies. It interacts with the Notch signaling pathway and may influence development and embryo formation. In hepatocellular carcinoma, UBR7 exhibits tumor suppressive functions by targeting the Keap1/Nrf2/Bach1/HK2 axis and inhibiting aerobic glycolysis. Additionally, UBR7 has been found to stimulate nucleotide biosynthesis in NOTCH1-driven processes. Recent research also suggests that UBR7, in concert with EZH2, inhibits TGF-β signaling, leading to suppression of triple-negative breast cancer invasion. These diverse functions highlight UBR7's importance in cellular regulation and disease pathogenesis.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- UBR7
- 基因别名
- C14orf130
- 蛋白别名
- ubiquitin protein ligase E3 component n-recognin 7; UBR7
- UniProt
- Q8N806
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- UBR7
- 蛋白名称
- ubiquitin protein ligase E3 component n-recognin 7
- 蛋白别名
- Putative E3 ubiquitin-protein ligase UBR7; N-recognin-7; RING-type E3 ubiquitin transferase UBR7
- 靶点基因名
- UBR7
- 基因别名
- C14orf130
- UniProt
- Q8N806
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG2a
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
YPDPEDEIPDEMIQCVVCEDWFHGRHLGAIPPESGDFQEMVCQACMKRCSFLWAYAAQLAVTKISTEDDGLVRNIDGIGDQEVIKPENGEHQDSTLKEDVPEQGKDDVREVKVEQNSEPCAGSSSESDLQTVFKNESLNAESKSGCKLQELKAKQLIKKDTATYWPLNWRSKLCTCQDCMKMYGDLDVLFLTDEYDTVLAYENKGKIAQATDRSDPLMDTLSSMNRVQQVELICEYNDLKTELKDYLKRFADEGTVVKREDIQQFFEEFQSKKRRRVDGM
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
UBR7 is a member of the UBR family of E3 ubiquitin ligases that plays important roles in various cellular processes and disease states. It functions as an H2BK120 monoubiquitin ligase and acts as a tumor suppressor in triple-negative breast cancer. UBR7 has been implicated in a neurodevelopmental syndrome characterized by intellectual disability, epilepsy, ptosis, hypothyroidism, and genital anomalies. It interacts with the Notch signaling pathway and may influence development and embryo formation. In hepatocellular carcinoma, UBR7 exhibits tumor suppressive functions by targeting the Keap1/Nrf2/Bach1/HK2 axis and inhibiting aerobic glycolysis. Additionally, UBR7 has been found to stimulate nucleotide biosynthesis in NOTCH1-driven processes. Recent research also suggests that UBR7, in concert with EZH2, inhibits TGF-β signaling, leading to suppression of triple-negative breast cancer invasion. These diverse functions highlight UBR7's importance in cellular regulation and disease pathogenesis.