抗 UBE3A 磁珠
02AB00086
The UBE3A gene encodes ubiquitin-protein ligase E3A, which plays a crucial role in the ubiquitin-proteasome pathway, targeting proteins for degradation within cells. This enzyme is involved in the regulation of various cellular processes, including apoptosis, cell cycle progression, and DNA repair. The UBE3A gene is located on chromosome 15 and is imprinted, meaning that only the maternal copy is active in the brain. Mutations in the UBE3A gene are associated with Angelman syndrome, a neurodevelopmental disorder characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, and absence of speech. The gene is also known to interact with the E6 protein of human papillomavirus types 16 and 18, promoting the degradation of tumor suppressor protein p53 and contributing to the development of HPV-associated cancers.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 宿主
- Mouse
- 靶点基因名
- UBE3A
- 基因别名
- E6AP; EPVE6AP; HPVE6A
- 蛋白别名
- ubiquitin protein ligase E3A; UBE3A
- UniProt
- Q05086
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- UBE3A
- 蛋白名称
- ubiquitin protein ligase E3A
- 蛋白别名
- Ubiquitin-protein ligase E3A; E6AP ubiquitin-protein ligase; HECT-type ubiquitin transferase E3A; Human papillomavirus E6-associated protein; Oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54
- 靶点基因名
- UBE3A
- 基因别名
- E6AP; EPVE6AP; HPVE6A
- UniProt
- Q05086
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
LQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEG
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
The UBE3A gene encodes ubiquitin-protein ligase E3A, which plays a crucial role in the ubiquitin-proteasome pathway, targeting proteins for degradation within cells. This enzyme is involved in the regulation of various cellular processes, including apoptosis, cell cycle progression, and DNA repair. The UBE3A gene is located on chromosome 15 and is imprinted, meaning that only the maternal copy is active in the brain. Mutations in the UBE3A gene are associated with Angelman syndrome, a neurodevelopmental disorder characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, and absence of speech. The gene is also known to interact with the E6 protein of human papillomavirus types 16 and 18, promoting the degradation of tumor suppressor protein p53 and contributing to the development of HPV-associated cancers.