抗 TRIML2 磁珠
02AB00095
TRIML2, an E3 ubiquitin ligase, plays a crucial role in various cellular processes, including regulating protein degradation and modulating immune responses. Its dysfunction is linked to several diseases, notably Trichorhinophalangeal Syndrome Type II, characterized by distinct skeletal and facial abnormalities. TRIML2's ubiquitination activity is essential for maintaining cellular homeostasis, and its impairment can lead to pathological conditions, including neurodegenerative diseases. Research indicates that TRIM family proteins, including TRIML2, are involved in critical pathways such as autophagy and apoptosis, emphasizing their potential as therapeutic targets in treating diseases associated with their dysfunction. Understanding the precise mechanisms by which TRIML2 operates could provide insights into its role in disease and pave the way for novel therapeutic strategies.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TRIML2
- 基因别名
- SPRYD6
- 蛋白别名
- tripartite motif family like 2; TRIML2
- UniProt
- Q8N7C3
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- TRIML2
- 蛋白名称
- tripartite motif family like 2
- 蛋白别名
- Probable E3 ubiquitin-protein ligase TRIML2; RING-type E3 ubiquitin transferase TRIML2; SPRY domain-containing protein 6; Tripartite motif family-like protein 2
- 靶点基因名
- TRIML2
- 基因别名
- SPRYD6
- UniProt
- Q8N7C3
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG2a
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
HNITEDAYCETHLEPTRLFCDVDQITLCSKCFQSQEHKHHMVCGIQEAAENYRKLFQEILNTSREKLEAAKSILTDEQERMAMIQEEEQNFKKMIESEYSMRLRLLNEECEQNLQRQQECISDLNLRETLLNQAIKLATELEEMFQEMLQ
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
TRIML2, an E3 ubiquitin ligase, plays a crucial role in various cellular processes, including regulating protein degradation and modulating immune responses. Its dysfunction is linked to several diseases, notably Trichorhinophalangeal Syndrome Type II, characterized by distinct skeletal and facial abnormalities. TRIML2's ubiquitination activity is essential for maintaining cellular homeostasis, and its impairment can lead to pathological conditions, including neurodegenerative diseases. Research indicates that TRIM family proteins, including TRIML2, are involved in critical pathways such as autophagy and apoptosis, emphasizing their potential as therapeutic targets in treating diseases associated with their dysfunction. Understanding the precise mechanisms by which TRIML2 operates could provide insights into its role in disease and pave the way for novel therapeutic strategies.