抗 TRIM72 磁珠
02AB00063
Tripartite motif-containing protein 72 (TRIM72), also known as MG53, is a muscle-specific protein that plays a critical role in cell membrane repair, particularly during muscle injury. It is characterized by its tripartite motif, which includes a RING finger domain and coiled-coil regions, enabling its function as an E3 ubiquitin ligase. TRIM72 is essential for the recruitment of repair machinery to damaged membranes, facilitating membrane fusion and exocytosis. Dysregulation of TRIM72 has been associated with several diseases, including Miyoshi muscular dystrophy, a genetic condition leading to muscle degeneration, and cardiac fibrosis, where it influences the proliferation and migration of cardiac fibroblasts through the TGF-β signaling pathway. Additionally, its role in muscle repair suggests potential implications in various muscular dystrophies and cardiomyopathies.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TRIM72
- 基因别名
- MG53
- 蛋白别名
- tripartite motif containing 72; TRIM72
- UniProt
- Q6ZMU5
- 物种
- Human, Rat
- 应用
- IP
产品详情
- 靶点名称
- TRIM72
- 蛋白名称
- tripartite motif containing 72
- 蛋白别名
- Tripartite motif-containing protein 72; Mitsugumin-53; Mg53
- 靶点基因名
- TRIM72
- 基因别名
- MG53
- UniProt
- Q6ZMU5
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human, Rat
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
FRALMPALEELTFDPSSAHPSLVVSSSGRRVECSEQKAPPAGEDPRQFDKAVAVVAHQQLSEGEHYWEVDVGDKPRWALGVIAAEAPRRGRLHAVPSQGLWLLGLREGKILEAHVEAKEPRALRSPERRPTRIGLYLSFGDGVLSFYDASDADALVPLFAFHERLPRPVYPFFDVCWHDKGKNAQPLLLV
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
Tripartite motif-containing protein 72 (TRIM72), also known as MG53, is a muscle-specific protein that plays a critical role in cell membrane repair, particularly during muscle injury. It is characterized by its tripartite motif, which includes a RING finger domain and coiled-coil regions, enabling its function as an E3 ubiquitin ligase. TRIM72 is essential for the recruitment of repair machinery to damaged membranes, facilitating membrane fusion and exocytosis. Dysregulation of TRIM72 has been associated with several diseases, including Miyoshi muscular dystrophy, a genetic condition leading to muscle degeneration, and cardiac fibrosis, where it influences the proliferation and migration of cardiac fibroblasts through the TGF-β signaling pathway. Additionally, its role in muscle repair suggests potential implications in various muscular dystrophies and cardiomyopathies.