抗 TRIM65 磁珠
02AB00094
TRIM65, a member of the tripartite motif (TRIM) protein family, functions primarily as an E3 ubiquitin ligase and is implicated in various diseases, particularly cancers and inflammatory conditions. Research indicates that TRIM65 promotes tumor progression by ubiquitinating key proteins involved in cell cycle regulation and apoptosis, such as Axin1 and p53, thereby facilitating the growth of cancers like renal cell carcinoma and colorectal cancer. Additionally, TRIM65 plays a significant role in innate immunity, particularly in the regulation of the NLRP3 inflammasome, where it negatively regulates its activation through ubiquitination, thus influencing inflammatory responses in diseases like atherosclerosis and gout. Despite its involvement in these critical biological processes, the full scope of TRIM65's functions and mechanisms remains underexplored, highlighting the need for further research to elucidate its potential as a therapeutic target in various diseases.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 宿主
- Mouse
- 靶点基因名
- TRIM65
- 蛋白别名
- tripartite motif containing 65; TRIM65
- UniProt
- Q6PJ69
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- TRIM65
- 蛋白名称
- tripartite motif containing 65
- 蛋白别名
- E3 ubiquitin-protein ligase TRIM65; Tripartite motif-containing protein 65
- 靶点基因名
- TRIM65
- UniProt
- Q6PJ69
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
DAERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQNSACILASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQRLRVHLEAVARHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPG
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
TRIM65, a member of the tripartite motif (TRIM) protein family, functions primarily as an E3 ubiquitin ligase and is implicated in various diseases, particularly cancers and inflammatory conditions. Research indicates that TRIM65 promotes tumor progression by ubiquitinating key proteins involved in cell cycle regulation and apoptosis, such as Axin1 and p53, thereby facilitating the growth of cancers like renal cell carcinoma and colorectal cancer. Additionally, TRIM65 plays a significant role in innate immunity, particularly in the regulation of the NLRP3 inflammasome, where it negatively regulates its activation through ubiquitination, thus influencing inflammatory responses in diseases like atherosclerosis and gout. Despite its involvement in these critical biological processes, the full scope of TRIM65's functions and mechanisms remains underexplored, highlighting the need for further research to elucidate its potential as a therapeutic target in various diseases.