抗 TRIM59 磁珠
02AB00126
TRIM59, a member of the tripartite motif-containing protein family, functions primarily as an E3 ubiquitin ligase and is implicated in various physiological processes, including immune responses and tumor progression. Its expression is associated with several diseases, particularly cancers, where it is often upregulated and linked to poor prognosis. For instance, TRIM59 has been shown to promote tumor cell proliferation and migration by regulating key proteins involved in cell cycle and apoptosis, thereby facilitating cancer development, notably in non-small cell lung cancer and gastric cancer. Additionally, TRIM59 plays a significant role in immune-related diseases; it modulates inflammatory responses and phagocytosis in macrophages, influencing conditions like sepsis. The manipulation of TRIM59 levels presents potential therapeutic avenues for treating immune disorders and malignancies, highlighting its significance in both immune regulation and oncogenesis.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TRIM59
- 基因别名
- RNF104; TRIM57; TSBF1
- 蛋白别名
- tripartite motif containing 59; TRIM59
- UniProt
- Q8IWR1
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- TRIM59
- 蛋白名称
- tripartite motif containing 59
- 蛋白别名
- Tripartite motif-containing protein 59; RING finger protein 104; Tumor suppressor TSBF-1
- 靶点基因名
- TRIM59
- 基因别名
- RNF104; TRIM57; TSBF1
- UniProt
- Q8IWR1
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Oligoclonal
- 亚型
- IgG
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
TRIM59, a member of the tripartite motif-containing protein family, functions primarily as an E3 ubiquitin ligase and is implicated in various physiological processes, including immune responses and tumor progression. Its expression is associated with several diseases, particularly cancers, where it is often upregulated and linked to poor prognosis. For instance, TRIM59 has been shown to promote tumor cell proliferation and migration by regulating key proteins involved in cell cycle and apoptosis, thereby facilitating cancer development, notably in non-small cell lung cancer and gastric cancer. Additionally, TRIM59 plays a significant role in immune-related diseases; it modulates inflammatory responses and phagocytosis in macrophages, influencing conditions like sepsis. The manipulation of TRIM59 levels presents potential therapeutic avenues for treating immune disorders and malignancies, highlighting its significance in both immune regulation and oncogenesis.