抗 TRIM5 磁珠
02AB00125
TRIM5 (Tripartite Motif Containing 5) is a crucial protein in the innate immune response, primarily known for its role in restricting retroviral infections, particularly HIV-1. It functions by recognizing and binding to the viral capsid, leading to the disassembly of the virus shortly after entry into the host cell. This antiviral activity is mediated through its RING domain, which also exhibits E3 ubiquitin ligase activity, influencing various signaling pathways involved in immune responses and inflammation. Moreover, polymorphisms in the TRIM5 gene have been associated with variations in HIV-1 infection outcomes, indicating its potential as a genetic factor influencing disease susceptibility. Beyond viral infections, TRIM5 has been implicated in autoimmune diseases such as systemic lupus erythematosus (SLE), where its expression correlates with disease severity, suggesting that it may also modulate immune responses in pathological contexts.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TRIM5
- 基因别名
- RNF88
- 蛋白别名
- tripartite motif containing 5; TRIM5
- UniProt
- Q9C035
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- TRIM5
- 蛋白名称
- tripartite motif containing 5
- 蛋白别名
- Tripartite motif-containing protein 5; RING finger protein 88; RING-type E3 ubiquitin transferase TRIM5
- 靶点基因名
- TRIM5
- 基因别名
- RNF88
- UniProt
- Q9C035
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
GHSFCQACLTANHKKSMLDKGESSCPVCRISYQPENIRPNRHVANIVEKLREVKLSPEGQKVDHCARHGEKLLLFCQEDGKVICWLCERSQEHRGHHTFLTEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQTQSLRELISDLEHRLQGSVMELLQGVDGVIKRTENVTLKKPETFPK
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
TRIM5 (Tripartite Motif Containing 5) is a crucial protein in the innate immune response, primarily known for its role in restricting retroviral infections, particularly HIV-1. It functions by recognizing and binding to the viral capsid, leading to the disassembly of the virus shortly after entry into the host cell. This antiviral activity is mediated through its RING domain, which also exhibits E3 ubiquitin ligase activity, influencing various signaling pathways involved in immune responses and inflammation. Moreover, polymorphisms in the TRIM5 gene have been associated with variations in HIV-1 infection outcomes, indicating its potential as a genetic factor influencing disease susceptibility. Beyond viral infections, TRIM5 has been implicated in autoimmune diseases such as systemic lupus erythematosus (SLE), where its expression correlates with disease severity, suggesting that it may also modulate immune responses in pathological contexts.