抗 TRIM49 磁珠
02AB00133
Tripartite motif-containing protein 49 (TRIM49) is part of the TRIM protein family, known for its role in various cellular functions, particularly in immune regulation and antiviral defense. TRIM49 is characterized by its RBCC (RING, B-box, and coiled-coil) structure, which enables it to act as an E3 ubiquitin ligase, facilitating post-translational modifications of target proteins. This function is crucial in regulating cellular processes such as proliferation, differentiation, and transcription. Dysregulation of TRIM49 has been implicated in several diseases, including inflammatory bowel disease (IBD), where it may contribute to the pathophysiology by affecting intestinal mucosal barriers and gene susceptibility. Additionally, TRIM49's involvement in cancer and autoimmune disorders highlights its potential as a therapeutic target.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TRIM49
- 基因别名
- RNF18
- 蛋白别名
- tripartite motif containing 49; TRIM49
- UniProt
- P0CI25
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- TRIM49
- 蛋白名称
- tripartite motif containing 49
- 蛋白别名
- Tripartite motif-containing protein 49; RING finger protein 18; Testis-specific RING-finger protein
- 靶点基因名
- TRIM49
- 基因别名
- RNF18
- UniProt
- P0CI25
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Oligoclonal
- 亚型
- IgG
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
Tripartite motif-containing protein 49 (TRIM49) is part of the TRIM protein family, known for its role in various cellular functions, particularly in immune regulation and antiviral defense. TRIM49 is characterized by its RBCC (RING, B-box, and coiled-coil) structure, which enables it to act as an E3 ubiquitin ligase, facilitating post-translational modifications of target proteins. This function is crucial in regulating cellular processes such as proliferation, differentiation, and transcription. Dysregulation of TRIM49 has been implicated in several diseases, including inflammatory bowel disease (IBD), where it may contribute to the pathophysiology by affecting intestinal mucosal barriers and gene susceptibility. Additionally, TRIM49's involvement in cancer and autoimmune disorders highlights its potential as a therapeutic target.