抗 TRIM47 磁珠
02AB00089
E3 ubiquitin-protein ligase TRIM47 (TRIM47) is a member of the tripartite motif (TRIM) protein family, characterized by its RING finger domain, which plays a crucial role in the ubiquitin-proteasome system (UPS). TRIM47 is involved in mediating the ubiquitination and subsequent degradation of various target proteins, thereby influencing cellular processes such as inflammation, synapse formation, and tumor progression. In the nervous system, TRIM47 is expressed in the hippocampus during synapse formation and is regulated by neuronal activity, particularly through NMDA receptor activation. Notably, TRIM47 has been implicated in the regulation of glioma cell proliferation and migration, as well as in pancreatic cancer progression. Furthermore, TRIM47 is upregulated during endothelial activation, contributing to inflammatory responses in conditions such as sepsis-induced acute lung injury by promoting K63-linked ubiquitination of TRAF2, thus activating NF-κB and MAPK signaling pathways.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TRIM47
- 基因别名
- GOA; RNF100
- 蛋白别名
- tripartite motif containing 47; TRIM47
- UniProt
- Q96LD4
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- TRIM47
- 蛋白名称
- tripartite motif containing 47
- 蛋白别名
- E3 ubiquitin-protein ligase TRIM47; Gene overexpressed in astrocytoma protein; RING finger protein 100; Tripartite motif-containing protein 47
- 靶点基因名
- TRIM47
- 基因别名
- GOA; RNF100
- UniProt
- Q96LD4
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG2a
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
PAPALAPEPSAPSALPSVPEPSAPCAPEPWPAGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHRLVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQEHRGHELVPLEQE
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
E3 ubiquitin-protein ligase TRIM47 (TRIM47) is a member of the tripartite motif (TRIM) protein family, characterized by its RING finger domain, which plays a crucial role in the ubiquitin-proteasome system (UPS). TRIM47 is involved in mediating the ubiquitination and subsequent degradation of various target proteins, thereby influencing cellular processes such as inflammation, synapse formation, and tumor progression. In the nervous system, TRIM47 is expressed in the hippocampus during synapse formation and is regulated by neuronal activity, particularly through NMDA receptor activation. Notably, TRIM47 has been implicated in the regulation of glioma cell proliferation and migration, as well as in pancreatic cancer progression. Furthermore, TRIM47 is upregulated during endothelial activation, contributing to inflammatory responses in conditions such as sepsis-induced acute lung injury by promoting K63-linked ubiquitination of TRAF2, thus activating NF-κB and MAPK signaling pathways.