抗 TRIM43B 磁珠
02AB00096
Tripartite motif-containing protein 43B (TRIM43B) is an E3 ubiquitin ligase that plays a vital role in various cellular processes, particularly in the regulation of immune responses and viral infections. Characterized by its RING finger, B-box, and coiled-coil domains, TRIM43B is involved in the ubiquitination of target proteins, facilitating their degradation and modulating signaling pathways. This protein has been shown to inhibit the lytic replication of several herpesviruses, including HSV-1 and KSHV, by targeting viral proteins for degradation, thus enhancing the host's antiviral defense. Dysregulation of TRIM43B has been linked to various diseases, particularly in the context of cancer, where its altered expression may contribute to tumorigenesis and progression. Additionally, its role in the immune response suggests that it may also influence autoimmune diseases.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TRIM43B
- 蛋白别名
- tripartite motif containing 43B; TRIM43B
- UniProt
- A6NCK2
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- TRIM43B
- 蛋白名称
- tripartite motif containing 43B
- 蛋白别名
- Tripartite motif-containing protein 43B
- 靶点基因名
- TRIM43B
- UniProt
- A6NCK2
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG2a
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
KMFCDMDKSLLCLLCSNSQEHGAHKHYPIEEAAEEDREKLLKQMRILWKKIQENQRNLYEERRTAFLLRGDVVLRAQMIRNEYRKLHPVLHKEEKQHLERLNKEYQEIFQQLQRSWVKMDQKSKHLKEMYQELMEMCHKP
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
Tripartite motif-containing protein 43B (TRIM43B) is an E3 ubiquitin ligase that plays a vital role in various cellular processes, particularly in the regulation of immune responses and viral infections. Characterized by its RING finger, B-box, and coiled-coil domains, TRIM43B is involved in the ubiquitination of target proteins, facilitating their degradation and modulating signaling pathways. This protein has been shown to inhibit the lytic replication of several herpesviruses, including HSV-1 and KSHV, by targeting viral proteins for degradation, thus enhancing the host's antiviral defense. Dysregulation of TRIM43B has been linked to various diseases, particularly in the context of cancer, where its altered expression may contribute to tumorigenesis and progression. Additionally, its role in the immune response suggests that it may also influence autoimmune diseases.