抗 TRIM34 磁珠
02AB00079
TRIM34 is an E3 ubiquitin ligase that plays significant roles in cellular processes, including antiviral defense and apoptosis regulation. It is induced by type I interferons, which are critical in the immune response to viral infections. The protein localizes to mitochondria, where it promotes apoptosis by disrupting mitochondrial membrane potential, leading to cytochrome c release and subsequent cell death. Dysregulation of TRIM34 has been implicated in various diseases, including cancer, where it may influence tumor progression and response to therapy. Studies have shown that TRIM34 can modulate immune signaling pathways, contributing to its role in both immune response and disease pathogenesis, highlighting its potential as a therapeutic target in conditions characterized by immune dysregulation or aberrant apoptosis[1][3][5].
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TRIM34
- 基因别名
- IFP1; RNF21
- 蛋白别名
- tripartite motif containing 34; TRIM34
- UniProt
- Q9BYJ4
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- TRIM34
- 蛋白名称
- tripartite motif containing 34
- 蛋白别名
- E3 ubiquitin-protein ligase TRIM34; Interferon-responsive finger protein 1; RING finger protein 21
- 靶点基因名
- TRIM34
- 基因别名
- IFP1; RNF21
- UniProt
- Q9BYJ4
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG2a
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
GEKLLLFCKEDRKVICWLCERSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAE
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
TRIM34 is an E3 ubiquitin ligase that plays significant roles in cellular processes, including antiviral defense and apoptosis regulation. It is induced by type I interferons, which are critical in the immune response to viral infections. The protein localizes to mitochondria, where it promotes apoptosis by disrupting mitochondrial membrane potential, leading to cytochrome c release and subsequent cell death. Dysregulation of TRIM34 has been implicated in various diseases, including cancer, where it may influence tumor progression and response to therapy. Studies have shown that TRIM34 can modulate immune signaling pathways, contributing to its role in both immune response and disease pathogenesis, highlighting its potential as a therapeutic target in conditions characterized by immune dysregulation or aberrant apoptosis[1][3][5].