抗 TRIM31 磁珠
02AB00138
E3 ubiquitin-protein ligase TRIM31 (TRIM31) is a member of the tripartite motif (TRIM) protein family, functions as an E3 ubiquitin ligase and plays a significant role in various cellular processes, including cell proliferation, inflammation, and tumorigenesis. Characterized by its RING finger, B-box, and coiled-coil domains, TRIM31 is involved in the ubiquitination of target proteins, regulating their stability and function. Notably, TRIM31 has been found to be upregulated in gastric adenocarcinoma, suggesting its potential as a biomarker for early-stage gastric cancer. Despite its overexpression in cancer tissues, TRIM31 can negatively regulate cell growth, indicating a complex role in tumor biology. Additionally, TRIM31 has been implicated in metabolic disorders, as it mitigates liver steatosis and insulin resistance by promoting the degradation of Rhbdf2, thereby improving insulin signaling and reducing inflammation.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TRIM31
- 基因别名
- C6orf13; RNF
- 蛋白别名
- tripartite motif containing 31; TRIM31
- UniProt
- Q9BZY9
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- TRIM31
- 蛋白名称
- tripartite motif containing 31
- 蛋白别名
- E3 ubiquitin-protein ligase TRIM31; Tripartite motif-containing protein 31
- 靶点基因名
- TRIM31
- 基因别名
- C6orf13; RNF
- UniProt
- Q9BZY9
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
KDHKSHNVSLIEEAAQNYQGQIQEQIQVLQQKEKETVQVKAQGVHRVDVFTDQVEHEKQRILTEFELLHQVLEEEKNFLLSRIYWLGHEGTEAGKHYVASTEPQLNDLKKLVDSLKTKQNMPPRQLLEDIKVVLCRSEEFQFLNPTPVPLELEKKLSEAKSRHDSITGSLKKFKDQLQADRKKDENRFFKSMNKNDMKSWGLLQKNNHKMNKTSEPGSSSAGGRTTSGPPNHHSSAPSHSLFRASSAGKVTFPVCLLASYDEISGQGASS
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
E3 ubiquitin-protein ligase TRIM31 (TRIM31) is a member of the tripartite motif (TRIM) protein family, functions as an E3 ubiquitin ligase and plays a significant role in various cellular processes, including cell proliferation, inflammation, and tumorigenesis. Characterized by its RING finger, B-box, and coiled-coil domains, TRIM31 is involved in the ubiquitination of target proteins, regulating their stability and function. Notably, TRIM31 has been found to be upregulated in gastric adenocarcinoma, suggesting its potential as a biomarker for early-stage gastric cancer. Despite its overexpression in cancer tissues, TRIM31 can negatively regulate cell growth, indicating a complex role in tumor biology. Additionally, TRIM31 has been implicated in metabolic disorders, as it mitigates liver steatosis and insulin resistance by promoting the degradation of Rhbdf2, thereby improving insulin signaling and reducing inflammation.