抗 TRIM25 磁珠
02AB00070
E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25) is an E3 ubiquitin ligase belonging to the tripartite motif (TRIM) protein family, plays a pivotal role in the innate immune response, particularly in antiviral defense. It is characterized by its SPRY/PRY domain, which allows it to function as an RNA-binding protein, enhancing its regulatory capabilities in gene expression. TRIM25 is essential for the activation of the RIG-I signaling pathway, which detects viral RNA and triggers an immune response. Its dysregulation has been implicated in various diseases, notably cancers such as hepatocellular carcinoma, where it can influence tumor progression and drug resistance by modulating pathways like PTEN/AKT. Additionally, TRIM25's involvement in inflammatory diseases highlights its significance beyond cancer.,E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25) is an E3 ubiquitin ligase belonging to the tripartite motif (TRIM) protein family, plays a pivotal role in the innate immune response, particularly in antiviral defense. It is characterized by its SPRY/PRY domain, which allows it to function as an RNA-binding protein, enhancing its regulatory capabilities in gene expression. TRIM25 is essential for the activation of the RIG-I signaling pathway, which detects viral RNA and triggers an immune response. Its dysregulation has been implicated in various diseases, notably cancers such as hepatocellular carcinoma, where it can influence tumor progression and drug resistance by modulating pathways like PTEN/AKT. Additionally, TRIM25's involvement in inflammatory diseases highlights its significance beyond cancer.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TRIM25
- 基因别名
- EFP; RNF147; ZNF147
- 蛋白别名
- tripartite motif containing 25; TRIM25
- UniProt
- Q14258
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- TRIM25
- 蛋白名称
- tripartite motif containing 25
- 蛋白别名
- E3 ubiquitin/ISG15 ligase TRIM25; Estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase; RING-type E3 ubiquitin transferase TRIM25; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147
- 靶点基因名
- TRIM25
- 基因别名
- EFP; RNF147; ZNF147
- UniProt
- Q14258
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
LSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTPSSGDPGEHDP
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25) is an E3 ubiquitin ligase belonging to the tripartite motif (TRIM) protein family, plays a pivotal role in the innate immune response, particularly in antiviral defense. It is characterized by its SPRY/PRY domain, which allows it to function as an RNA-binding protein, enhancing its regulatory capabilities in gene expression. TRIM25 is essential for the activation of the RIG-I signaling pathway, which detects viral RNA and triggers an immune response. Its dysregulation has been implicated in various diseases, notably cancers such as hepatocellular carcinoma, where it can influence tumor progression and drug resistance by modulating pathways like PTEN/AKT. Additionally, TRIM25's involvement in inflammatory diseases highlights its significance beyond cancer.,E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25) is an E3 ubiquitin ligase belonging to the tripartite motif (TRIM) protein family, plays a pivotal role in the innate immune response, particularly in antiviral defense. It is characterized by its SPRY/PRY domain, which allows it to function as an RNA-binding protein, enhancing its regulatory capabilities in gene expression. TRIM25 is essential for the activation of the RIG-I signaling pathway, which detects viral RNA and triggers an immune response. Its dysregulation has been implicated in various diseases, notably cancers such as hepatocellular carcinoma, where it can influence tumor progression and drug resistance by modulating pathways like PTEN/AKT. Additionally, TRIM25's involvement in inflammatory diseases highlights its significance beyond cancer.