抗 TRAF3 磁珠
02AB00124
TRAF3 is an E3 ubiquitin ligase that plays a crucial role in regulating immune responses and various cellular processes through ubiquitination. It is involved in the signaling pathways of several receptors, including Toll-like receptors (TLRs) and lymphotoxin β receptor (LTβR), where it modulates the activation of transcription factors like NF-κB. Dysregulation of TRAF3 has been linked to several diseases, including autoimmune disorders and cancers. For instance, mutations or alterations in TRAF3 can lead to impaired immune responses, as seen in conditions such as herpes simplex encephalitis due to its role in TLR signaling. Additionally, TRAF3's degradation, often mediated by other E3 ligases like cIAP, can disrupt normal cellular signaling, contributing to inflammatory diseases and malignancies. Understanding TRAF3's multifaceted roles offers insights into potential therapeutic targets for these diseases.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TRAF3
- 基因别名
- CAP-1; CRAF1; TRAFAMN
- 蛋白别名
- TNF receptor associated factor 3; TRAF3
- UniProt
- Q13114
- 物种
- Human, Mouse
- 应用
- IP
产品详情
- 靶点名称
- TRAF3
- 蛋白名称
- TNF receptor associated factor 3
- 蛋白别名
- TNF receptor-associated factor 3; CD40 receptor-associated factor 1; CRAF1; CD40-binding protein; CD40BP; LMP1-associated protein 1; LAP1; RING-type E3 ubiquitin transferase TRAF3
- 靶点基因名
- TRAF3
- 基因别名
- CAP-1; CRAF1; TRAFAMN
- UniProt
- Q13114
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human, Mouse
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
HEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLA
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
TRAF3 is an E3 ubiquitin ligase that plays a crucial role in regulating immune responses and various cellular processes through ubiquitination. It is involved in the signaling pathways of several receptors, including Toll-like receptors (TLRs) and lymphotoxin β receptor (LTβR), where it modulates the activation of transcription factors like NF-κB. Dysregulation of TRAF3 has been linked to several diseases, including autoimmune disorders and cancers. For instance, mutations or alterations in TRAF3 can lead to impaired immune responses, as seen in conditions such as herpes simplex encephalitis due to its role in TLR signaling. Additionally, TRAF3's degradation, often mediated by other E3 ligases like cIAP, can disrupt normal cellular signaling, contributing to inflammatory diseases and malignancies. Understanding TRAF3's multifaceted roles offers insights into potential therapeutic targets for these diseases.