抗 TANK 磁珠
02AB00083
TANK is a crucial regulator of NF-κB signaling, playing a significant role in immune responses and inflammation. TANK acts as a negative regulator of NF-κB activation induced by DNA damage, interleukin-1β, and Toll-like receptor stimulation. It forms a complex with MCPIP1 and the deubiquitinase USP10, which facilitates the deubiquitination of TRAF6, thereby inhibiting NF-κB activation. This regulatory function of TANK is essential for maintaining the balance of inflammatory responses and preventing excessive inflammation. In terms of disease associations, TANK has been linked to enhanced aversive emotional processing, which may protect against the development of alcohol drinking behavior. Additionally, the TANK-mediated regulation of NF-κB signaling is crucial in various immune-related processes, including T-cell activation and differentiation, which are implicated in autoimmune diseases and inflammatory disorders.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- TANK
- 基因别名
- ITRAF; TRAF2
- 蛋白别名
- TRAF family member associated NFKB activator; TANK
- UniProt
- Q92844
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- TANK
- 蛋白名称
- TRAF family member associated NFKB activator
- 蛋白别名
- TRAF family member-associated NF-kappa-B activator; TRAF-interacting protein; I-TRAF
- 靶点基因名
- TANK
- 基因别名
- ITRAF; TRAF2
- UniProt
- Q92844
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
KAYEAFRQACMDRDSAVKELQQKTENYEQRIREQQEQLSLQQTIIDKLKSQLLLVNSTQDNNYGCVPLLEDSETRKNNLTLDQPQDKVISGIAREKLPKVRRQEVSSPRK
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
TANK is a crucial regulator of NF-κB signaling, playing a significant role in immune responses and inflammation. TANK acts as a negative regulator of NF-κB activation induced by DNA damage, interleukin-1β, and Toll-like receptor stimulation. It forms a complex with MCPIP1 and the deubiquitinase USP10, which facilitates the deubiquitination of TRAF6, thereby inhibiting NF-κB activation. This regulatory function of TANK is essential for maintaining the balance of inflammatory responses and preventing excessive inflammation. In terms of disease associations, TANK has been linked to enhanced aversive emotional processing, which may protect against the development of alcohol drinking behavior. Additionally, the TANK-mediated regulation of NF-κB signaling is crucial in various immune-related processes, including T-cell activation and differentiation, which are implicated in autoimmune diseases and inflammatory disorders.