抗 SHPRH 磁珠
02AB00061
SHPRH (SNF2 Histone Linker PHD RING Helicase) is an E3 ubiquitin ligase that plays a crucial role in DNA damage tolerance and repair mechanisms. It facilitates the transfer of ubiquitin to target proteins, particularly during genotoxic stress, which is essential for maintaining genomic stability. Dysregulation of SHPRH has been implicated in various diseases, including cancer, where its altered expression can lead to impaired DNA repair processes, contributing to tumorigenesis. Studies have shown that SHPRH interacts with other proteins involved in DNA repair, highlighting its significance in cellular responses to DNA damage. Furthermore, understanding the functional implications of SHPRH in disease contexts may provide insights into potential therapeutic targets for cancer treatment and other disorders related to genomic instability.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- SHPRH
- 基因别名
- KIAA2023
- 蛋白别名
- SNF2 histone linker PHD RING helicase; SHPRH
- UniProt
- Q149N8
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- SHPRH
- 蛋白名称
- SNF2 histone linker PHD RING helicase
- 蛋白别名
- E3 ubiquitin-protein ligase SHPRH; RING-type E3 ubiquitin transferase SHPRH; SNF2; histone-linker; PHD and RING finger domain-containing helicase
- 靶点基因名
- SHPRH
- 基因别名
- KIAA2023
- UniProt
- Q149N8
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
DKTKKQAVGSPRKIQKETRKSGNKDTDSEYLPSDTSDDDDDPYYYYYKSRRNRSKLRKKLVPSTKKGKSQPFINPDSQGHCPATSDSGITDVAMSKSTCISEFNQEHETEDCAESLNHADSDVPPSNTMSPFNTSDYRFECICGELDQIDRKPRVQCLKCHLWQHAKCVN
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
SHPRH (SNF2 Histone Linker PHD RING Helicase) is an E3 ubiquitin ligase that plays a crucial role in DNA damage tolerance and repair mechanisms. It facilitates the transfer of ubiquitin to target proteins, particularly during genotoxic stress, which is essential for maintaining genomic stability. Dysregulation of SHPRH has been implicated in various diseases, including cancer, where its altered expression can lead to impaired DNA repair processes, contributing to tumorigenesis. Studies have shown that SHPRH interacts with other proteins involved in DNA repair, highlighting its significance in cellular responses to DNA damage. Furthermore, understanding the functional implications of SHPRH in disease contexts may provide insights into potential therapeutic targets for cancer treatment and other disorders related to genomic instability.