抗 SH3RF1 磁珠
02AB00075
SH3RF1 is an E3 ubiquitin ligase that plays important roles in cell death response to apoptotic stimuli and regulation of calcium homeostasis. It is involved in various cellular processes, including the JNK signaling pathway and regulation of NFκB nuclear translocation. SH3RF1 has been implicated in several diseases, particularly cancer and neurodegenerative disorders. In cancer, it has been identified as a regulator of FAT1 cadherin, a protein associated with various cancers. SH3RF1 interacts with FAT1 through its N-terminal SH3 domains and regulates FAT1 protein levels, potentially influencing cancer progression. In neurodegenerative diseases, SH3RF1 has been linked to neuronal migration and regulation of T cell differentiation. Its involvement in immune-related pathways suggests a potential role in the immune component of neurodegeneration, which could have implications for developing new therapeutic strategies or repurposing existing immunotherapies for neurodegenerative diseases.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- SH3RF1
- 基因别名
- KIAA1494; POSH; POSH1; RNF142; SH3MD2
- 蛋白别名
- SH3 domain containing ring finger 1; SH3RF1
- UniProt
- Q7Z6J0
- 物种
- Human, Mouse
- 应用
- IP
产品详情
- 靶点名称
- SH3RF1
- 蛋白名称
- SH3 domain containing ring finger 1
- 蛋白别名
- E3 ubiquitin-protein ligase SH3RF1; Plenty of SH3s; Protein POSH; RING finger protein 142; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; SH3 multiple domains protein 2
- 靶点基因名
- SH3RF1
- 基因别名
- KIAA1494; POSH; POSH1; RNF142; SH3MD2
- UniProt
- Q7Z6J0
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human, Mouse
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
GNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLF
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
SH3RF1 is an E3 ubiquitin ligase that plays important roles in cell death response to apoptotic stimuli and regulation of calcium homeostasis. It is involved in various cellular processes, including the JNK signaling pathway and regulation of NFκB nuclear translocation. SH3RF1 has been implicated in several diseases, particularly cancer and neurodegenerative disorders. In cancer, it has been identified as a regulator of FAT1 cadherin, a protein associated with various cancers. SH3RF1 interacts with FAT1 through its N-terminal SH3 domains and regulates FAT1 protein levels, potentially influencing cancer progression. In neurodegenerative diseases, SH3RF1 has been linked to neuronal migration and regulation of T cell differentiation. Its involvement in immune-related pathways suggests a potential role in the immune component of neurodegeneration, which could have implications for developing new therapeutic strategies or repurposing existing immunotherapies for neurodegenerative diseases.