抗 RNF32 磁珠
02AB00060
RNF32 plays a crucial role in various cellular processes, particularly in ubiquitination, where it functions as an E3 ubiquitin ligase. This activity is essential for protein degradation and regulation within the cell. Dysregulation of RNF32 has been implicated in several diseases, including neurodegenerative disorders and hereditary motor neuron diseases, such as Distal Hereditary Motor Neuronopathy. The protein's involvement in these conditions suggests that it may contribute to neurodegeneration through mechanisms like impaired protein homeostasis and cellular stress responses. Additionally, RNF32's interactions with other proteins and its role in immune responses further highlight its significance in disease pathogenesis, making it a potential target for therapeutic interventions in related disorders.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- RNF32
- 蛋白别名
- ring finger protein 32; RNF32
- UniProt
- Q9H0A6
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- RNF32
- 蛋白名称
- ring finger protein 32
- 蛋白别名
- RING finger protein 32
- 靶点基因名
- RNF32
- UniProt
- Q9H0A6
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
KDNLAVNAVALQDHILHDLQLRNLSVADHSKTQVQKKENKSLKRDTKAIIDTGLKKTTQCPKLEDSEKEYVLDPKPPPLTLAQKLGLIGPPPPPLSSDEW
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
RNF32 plays a crucial role in various cellular processes, particularly in ubiquitination, where it functions as an E3 ubiquitin ligase. This activity is essential for protein degradation and regulation within the cell. Dysregulation of RNF32 has been implicated in several diseases, including neurodegenerative disorders and hereditary motor neuron diseases, such as Distal Hereditary Motor Neuronopathy. The protein's involvement in these conditions suggests that it may contribute to neurodegeneration through mechanisms like impaired protein homeostasis and cellular stress responses. Additionally, RNF32's interactions with other proteins and its role in immune responses further highlight its significance in disease pathogenesis, making it a potential target for therapeutic interventions in related disorders.