抗 RNF146 磁珠
02AB00072
RNF146, also known as Iduna, is a novel E3 ubiquitin ligase that plays a critical role in cellular processes by interacting with poly(ADP-ribose) (PAR). Its primary function involves regulating cell death pathways, particularly by inhibiting Parthanatos, a form of cell death linked to neurodegenerative diseases. Elevated expression of RNF146 has been observed in the brains of Alzheimer's disease (AD) patients, suggesting its involvement in neuroprotection against excitotoxicity and potential roles in the early stages of neurodegeneration. Additionally, RNF146 has been implicated in cancer development, particularly breast cancer, where it may influence Wnt signaling and modulate the effects of PARP inhibitors in BRCA1/2-deficient tumors. This dual role in both neuroprotection and tumorigenesis highlights RNF146's significance in health and disease, warranting further investigation into its therapeutic potential in neurodegenerative and oncological contexts.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- RNF146
- 蛋白别名
- ring finger protein 146; RNF146
- UniProt
- Q9NTX7
- 物种
- Human, Rat
- 应用
- IP
产品详情
- 靶点名称
- RNF146
- 蛋白名称
- ring finger protein 146
- 蛋白别名
- E3 ubiquitin-protein ligase RNF146; Dactylidin; Iduna; RING finger protein 146; RING-type E3 ubiquitin transferase RNF146
- 靶点基因名
- RNF146
- UniProt
- Q9NTX7
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human, Rat
- 克隆性
- Monoclonal
- 亚型
- IgG2b
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
NLARESSADGADSVSAQSGASVQPLVSSVRPLTSVDGQLTSPATPSPDASTSLEDSFAHLQLSGDNTAERSHRGEGEEDHESPSSGRVPAPDTSIEETESDASSDSEDVSAVVAQHSLTQQRLLVSNANQ
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
RNF146, also known as Iduna, is a novel E3 ubiquitin ligase that plays a critical role in cellular processes by interacting with poly(ADP-ribose) (PAR). Its primary function involves regulating cell death pathways, particularly by inhibiting Parthanatos, a form of cell death linked to neurodegenerative diseases. Elevated expression of RNF146 has been observed in the brains of Alzheimer's disease (AD) patients, suggesting its involvement in neuroprotection against excitotoxicity and potential roles in the early stages of neurodegeneration. Additionally, RNF146 has been implicated in cancer development, particularly breast cancer, where it may influence Wnt signaling and modulate the effects of PARP inhibitors in BRCA1/2-deficient tumors. This dual role in both neuroprotection and tumorigenesis highlights RNF146's significance in health and disease, warranting further investigation into its therapeutic potential in neurodegenerative and oncological contexts.