抗 RNF113B 磁珠
02AB00064
RING finger protein 113B (RNF113B) is an E3 ubiquitin ligase that plays a significant role in the ubiquitin-proteasome system, facilitating the ubiquitination of target proteins for degradation. This protein is characterized by its RING finger domain, which is essential for its ligase activity. RNF113B is involved in various cellular processes, including cell cycle regulation, apoptosis, and DNA damage response. Dysregulation of RNF113B has been implicated in several diseases, particularly in certain cancers, where its altered expression can contribute to tumorigenesis by affecting protein stability and signaling pathways. For instance, aberrant RNF113B activity may lead to the accumulation of oncoproteins, promoting uncontrolled cell growth and proliferation. Additionally, its role in the immune response suggests that RNF113B may also influence autoimmune diseases.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- RNF113B
- 基因别名
- RNF161; ZNF183L1
- 蛋白别名
- ring finger protein 113B; RNF113B
- UniProt
- Q8IZP6
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- RNF113B
- 蛋白名称
- ring finger protein 113B
- 蛋白别名
- RING finger protein 113B; Zinc finger protein 183-like 1
- 靶点基因名
- RNF113B
- 基因别名
- RNF161; ZNF183L1
- UniProt
- Q8IZP6
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG2a
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
DVVYRSTRSAKPVGPEDMGATADFEQDTEKEHHTPTILKCSQRVQEALRGREHDHIYRGIHSYLRYLKPKDTSMGNSSSGMARKGPIRAPGHLRATVRWDYQPDICKDYKETGFCGFGDSCKFLHDRSDYKLGWEIERELEEGRYCICEDENHEVGSEEEEIPFRCFICRQAFQNPVVTK
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
RING finger protein 113B (RNF113B) is an E3 ubiquitin ligase that plays a significant role in the ubiquitin-proteasome system, facilitating the ubiquitination of target proteins for degradation. This protein is characterized by its RING finger domain, which is essential for its ligase activity. RNF113B is involved in various cellular processes, including cell cycle regulation, apoptosis, and DNA damage response. Dysregulation of RNF113B has been implicated in several diseases, particularly in certain cancers, where its altered expression can contribute to tumorigenesis by affecting protein stability and signaling pathways. For instance, aberrant RNF113B activity may lead to the accumulation of oncoproteins, promoting uncontrolled cell growth and proliferation. Additionally, its role in the immune response suggests that RNF113B may also influence autoimmune diseases.