抗 RMND5A 磁珠
02AB00088
RMND5A is a core component of the CTLH E3 ubiquitin-protein ligase complex, which plays a crucial role in protein ubiquitination and degradation. This gene has been associated with various diseases and biological processes. In the central nervous system, RMND5A deficiency has been linked to ciliary dyskinesia and lissencephaly. The protein is involved in cell migration, adhesion, and nuclear functions, as well as cell proliferation, death, and survival pathways. RMND5A has also been implicated in hematopoietic stem cell specification and erythrocyte development. Recent research has shown that RMND5A is highly expressed in pancreatic adenocarcinoma and is associated with overall patient survival. The CTLH complex, of which RMND5A is a part, has been found to target specific proteins for degradation, suggesting its importance in cellular homeostasis and potential involvement in various pathological conditions.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- RMND5A
- 蛋白别名
- required for meiotic nuclear division 5 homolog A; RMND5A
- UniProt
- Q9H871
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- RMND5A
- 蛋白名称
- required for meiotic nuclear division 5 homolog A
- 蛋白别名
- E3 ubiquitin-protein transferase RMND5A; P44CTLH; Protein RMD5 homolog A
- 靶点基因名
- RMND5A
- UniProt
- Q9H871
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
ELIDYTGGLKHEILQSHGQDAELSGTLSLVLTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQADSQRLLNEVMVEHFFRQGMLDVAEELCQESGLSVDPSQ
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
RMND5A is a core component of the CTLH E3 ubiquitin-protein ligase complex, which plays a crucial role in protein ubiquitination and degradation. This gene has been associated with various diseases and biological processes. In the central nervous system, RMND5A deficiency has been linked to ciliary dyskinesia and lissencephaly. The protein is involved in cell migration, adhesion, and nuclear functions, as well as cell proliferation, death, and survival pathways. RMND5A has also been implicated in hematopoietic stem cell specification and erythrocyte development. Recent research has shown that RMND5A is highly expressed in pancreatic adenocarcinoma and is associated with overall patient survival. The CTLH complex, of which RMND5A is a part, has been found to target specific proteins for degradation, suggesting its importance in cellular homeostasis and potential involvement in various pathological conditions.