抗 PPIL2 磁珠
02AB00122
PPIL2 is a member of the cyclophilin family, functioning primarily as a U-box-type E3 ubiquitin ligase. This enzyme plays a crucial role in modulating protein stability and degradation, particularly in the context of cancer. Research indicates that PPIL2 is involved in suppressing the epithelial-mesenchymal transition (EMT), a critical process in cancer metastasis, by promoting the degradation of the EMT transcription factor SNAI1. Elevated levels of PPIL2 have been correlated with reduced invasion and metastasis in breast cancer models, suggesting its potential as a therapeutic target. Additionally, PPIL2's expression is influenced by cyclosporine A (CsA), an immunosuppressant, which further implicates its role in cancer biology. Overall, PPIL2's functions in protein regulation and its involvement in cancer progression highlight its significance in understanding disease mechanisms and developing treatment strategies.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- PPIL2
- 蛋白别名
- peptidylprolyl isomerase like 2; PPIL2
- UniProt
- Q13356
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- PPIL2
- 蛋白名称
- peptidylprolyl isomerase like 2
- 蛋白别名
- RING-type E3 ubiquitin-protein ligase PPIL2; CYC4; Cyclophilin-60; Cyclophilin-like protein Cyp-60; Cyp60; hCyP-60; Probable inactive peptidyl-prolyl cis-trans isomerase-like 2; PPIase; Rotamase PPIL2
- 靶点基因名
- PPIL2
- UniProt
- Q13356
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
YVRLHTNKGDLNLELHCDLTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDKKHTIFGRVVGGFDVLTAMENVESDPKTDRPKEEIRIDATTVFVDPYEEADAQIAQERKTQLKVAPETKVKSSQPQAGS
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
PPIL2 is a member of the cyclophilin family, functioning primarily as a U-box-type E3 ubiquitin ligase. This enzyme plays a crucial role in modulating protein stability and degradation, particularly in the context of cancer. Research indicates that PPIL2 is involved in suppressing the epithelial-mesenchymal transition (EMT), a critical process in cancer metastasis, by promoting the degradation of the EMT transcription factor SNAI1. Elevated levels of PPIL2 have been correlated with reduced invasion and metastasis in breast cancer models, suggesting its potential as a therapeutic target. Additionally, PPIL2's expression is influenced by cyclosporine A (CsA), an immunosuppressant, which further implicates its role in cancer biology. Overall, PPIL2's functions in protein regulation and its involvement in cancer progression highlight its significance in understanding disease mechanisms and developing treatment strategies.