抗 PML 磁珠
02AB00076
Promyelocytic leukemia protein (PML) is a tumor suppressor protein that plays a crucial role in regulating cellular processes such as cell cycle progression, apoptosis, senescence, and DNA repair. PML forms subnuclear structures called PML nuclear bodies (PML-NBs) that serve as platforms for the recruitment and regulation of various proteins involved in these pathways. Disruption of PML function, often due to chromosomal translocations or downregulation, is frequently observed in cancer cells and is associated with increased cell survival, proliferation, and genomic instability. PML inactivation can occur at transcriptional, translational, or post-translational levels, leading to dysregulation of tumor suppressive pathways, particularly those involving p53. Understanding the regulation of PML and its role in tumor suppression may provide potential therapeutic opportunities for treating PML-related diseases.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- PML
- 基因别名
- MYL; PP8675; RNF71; TRIM19
- 蛋白别名
- PML nuclear body scaffold; PML
- UniProt
- P29590
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- PML
- 蛋白名称
- PML nuclear body scaffold
- 蛋白别名
- Protein PML; E3 SUMO-protein ligase PML; Promyelocytic leukemia protein; RING finger protein 71; RING-type E3 SUMO transferase PML; Tripartite motif-containing protein 19; TRIM19
- 靶点基因名
- PML
- 基因别名
- MYL; PP8675; RNF71; TRIM19
- UniProt
- P29590
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLPNSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENLADPQAEDRPLVFFDLKIDNETQKISQLAAV
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
Promyelocytic leukemia protein (PML) is a tumor suppressor protein that plays a crucial role in regulating cellular processes such as cell cycle progression, apoptosis, senescence, and DNA repair. PML forms subnuclear structures called PML nuclear bodies (PML-NBs) that serve as platforms for the recruitment and regulation of various proteins involved in these pathways. Disruption of PML function, often due to chromosomal translocations or downregulation, is frequently observed in cancer cells and is associated with increased cell survival, proliferation, and genomic instability. PML inactivation can occur at transcriptional, translational, or post-translational levels, leading to dysregulation of tumor suppressive pathways, particularly those involving p53. Understanding the regulation of PML and its role in tumor suppression may provide potential therapeutic opportunities for treating PML-related diseases.