抗 NEDD4 磁珠
02AB00078
NEDD4 (neural precursor cell expressed developmentally downregulated 4) is a member of the HECT E3 ubiquitin ligase family that plays crucial roles in various cellular processes and diseases. NEDD4 regulates the ubiquitination and degradation of numerous substrates, including oncogenes, tumor suppressors, and ion channels, through K48- and K63-linked polyubiquitination. It is involved in cell proliferation, differentiation, migration, invasion, apoptosis, autophagy, and DNA damage response. Dysregulation of NEDD4 has been implicated in various diseases, such as cancers, neurodegenerative diseases, and polycystic kidney disease. For example, NEDD4 can promote the degradation of α-synuclein, a key protein involved in Parkinson's disease pathogenesis, through K63-linked polyubiquitination. Inhibiting NEDD4 activity may enhance the clearance of toxic proteins and slow disease progression.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- NEDD4
- 基因别名
- KIAA0093; NEDD4-1; RPF1
- 蛋白别名
- NEDD4 E3 ubiquitin protein ligase; NEDD4
- UniProt
- P46934
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- NEDD4
- 蛋白名称
- NEDD4 E3 ubiquitin protein ligase
- 蛋白别名
- E3 ubiquitin-protein ligase NEDD4; Cell proliferation-inducing gene 53 protein; HECT-type E3 ubiquitin transferase NEDD4; Neural precursor cell expressed developmentally down-regulated protein 4; NEDD-4
- 靶点基因名
- NEDD4
- 基因别名
- KIAA0093; NEDD4-1; RPF1
- UniProt
- P46934
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
NARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQ
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
NEDD4 (neural precursor cell expressed developmentally downregulated 4) is a member of the HECT E3 ubiquitin ligase family that plays crucial roles in various cellular processes and diseases. NEDD4 regulates the ubiquitination and degradation of numerous substrates, including oncogenes, tumor suppressors, and ion channels, through K48- and K63-linked polyubiquitination. It is involved in cell proliferation, differentiation, migration, invasion, apoptosis, autophagy, and DNA damage response. Dysregulation of NEDD4 has been implicated in various diseases, such as cancers, neurodegenerative diseases, and polycystic kidney disease. For example, NEDD4 can promote the degradation of α-synuclein, a key protein involved in Parkinson's disease pathogenesis, through K63-linked polyubiquitination. Inhibiting NEDD4 activity may enhance the clearance of toxic proteins and slow disease progression.