抗 MDM4 磁珠
02AB00085
MDM4 is a critical regulator of the tumor suppressor protein p53, playing a significant role in cellular functions and disease mechanisms. It negatively regulates p53 activity, thereby influencing cell growth, stress responses, and apoptosis. MDM4's dysregulation is associated with various cancers, as it can lead to diminished p53 function, allowing uncontrolled cell proliferation. Studies have shown that loss-of-function mutations in MDM4 result in p53 hyperactivity, which can lead to hematological disorders, such as bone marrow failure. Additionally, MDM4 interacts with MDM2, another key regulator of p53, forming a complex network that governs p53's stability and activity. Targeting MDM4 for therapeutic interventions is being explored to restore p53 function in cancer and other diseases, highlighting its potential as a promising target for cancer therapies.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- MDM4
- 基因别名
- MDMX
- 蛋白别名
- MDM4 regulator of p53; MDM4
- UniProt
- O15151
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- MDM4
- 蛋白名称
- MDM4 regulator of p53
- 蛋白别名
- Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4
- 靶点基因名
- MDM4
- 基因别名
- MDMX
- UniProt
- O15151
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
TATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
MDM4 is a critical regulator of the tumor suppressor protein p53, playing a significant role in cellular functions and disease mechanisms. It negatively regulates p53 activity, thereby influencing cell growth, stress responses, and apoptosis. MDM4's dysregulation is associated with various cancers, as it can lead to diminished p53 function, allowing uncontrolled cell proliferation. Studies have shown that loss-of-function mutations in MDM4 result in p53 hyperactivity, which can lead to hematological disorders, such as bone marrow failure. Additionally, MDM4 interacts with MDM2, another key regulator of p53, forming a complex network that governs p53's stability and activity. Targeting MDM4 for therapeutic interventions is being explored to restore p53 function in cancer and other diseases, highlighting its potential as a promising target for cancer therapies.