抗 MAGEA3 磁珠
02AB00117
MAGEA3 is a cancer/testis antigen primarily expressed in testicular germ cells and various cancer types, including gastric cancer, lung adenocarcinoma, and undifferentiated pleomorphic sarcoma. While its normal function remains largely unknown, MAGEA3 overexpression in tumors is associated with poor prognosis and increased metastasis. MAGEA3 expression correlates with immune cell infiltration in the tumor microenvironment, potentially affecting the efficacy of immunotherapies. High MAGEA3 expression is linked to immune suppression in gastric cancer and negatively correlates with infiltration of CD8+ T cells, B cells, and dendritic cells in lung adenocarcinoma. Due to its tumor-specific expression and immunogenicity, MAGEA3 is considered a promising target for cancer immunotherapy, including cancer vaccines and adoptive T cell therapies. However, its role in tumor progression and immune evasion requires further investigation to fully exploit its potential as a therapeutic target.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- MAGEA3
- 基因别名
- MAGE3
- 蛋白别名
- MAGE family member A3; MAGEA3
- UniProt
- P43357
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- MAGEA3
- 蛋白名称
- MAGE family member A3
- 蛋白别名
- Melanoma-associated antigen 3; Antigen MZ2-D; Cancer/testis antigen 1.3; CT1.3; MAGE-3 antigen
- 靶点基因名
- MAGEA3
- 基因别名
- MAGE3
- UniProt
- P43357
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
MAGEA3 is a cancer/testis antigen primarily expressed in testicular germ cells and various cancer types, including gastric cancer, lung adenocarcinoma, and undifferentiated pleomorphic sarcoma. While its normal function remains largely unknown, MAGEA3 overexpression in tumors is associated with poor prognosis and increased metastasis. MAGEA3 expression correlates with immune cell infiltration in the tumor microenvironment, potentially affecting the efficacy of immunotherapies. High MAGEA3 expression is linked to immune suppression in gastric cancer and negatively correlates with infiltration of CD8+ T cells, B cells, and dendritic cells in lung adenocarcinoma. Due to its tumor-specific expression and immunogenicity, MAGEA3 is considered a promising target for cancer immunotherapy, including cancer vaccines and adoptive T cell therapies. However, its role in tumor progression and immune evasion requires further investigation to fully exploit its potential as a therapeutic target.