抗 LONRF2 磁珠
02AB00140
LON peptidase N-terminal domain and RING finger protein 2 (LONRF2) is a protein that plays a significant role in cellular processes, particularly in protein quality control and ubiquitination. Characterized by its LON peptidase N-terminal domain and RING finger domain, LONRF2 functions as an E3 ubiquitin ligase, facilitating the ubiquitination of target proteins, which regulates their degradation and activity. It is expressed in various tissues, including the brain, immune system, and gastrointestinal tract. LONRF2 has been linked to diseases such as Immunodeficiency 15B, a genetic disorder that leads to recurrent infections and autoimmune issues, and childhood-onset inflammatory bowel disease, which affects gastrointestinal health. Recent studies suggest that LONRF2 is crucial for maintaining protein homeostasis, especially in post-mitotic cells, and its deficiency may lead to neurological deficits, underscoring its importance in both immune regulation and neuroprotection.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 宿主
- Mouse
- 靶点基因名
- LONRF2
- 基因别名
- RNF192
- 蛋白别名
- LON peptidase N-terminal domain and ring finger 2; LONRF2
- UniProt
- Q1L5Z9
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- LONRF2
- 蛋白名称
- LON peptidase N-terminal domain and ring finger 2
- 蛋白别名
- LON peptidase N-terminal domain and RING finger protein 2; Neuroblastoma apoptosis-related protease; RING finger protein 192
- 靶点基因名
- LONRF2
- 基因别名
- RNF192
- UniProt
- Q1L5Z9
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Oligoclonal
- 亚型
- IgG
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
LON peptidase N-terminal domain and RING finger protein 2 (LONRF2) is a protein that plays a significant role in cellular processes, particularly in protein quality control and ubiquitination. Characterized by its LON peptidase N-terminal domain and RING finger domain, LONRF2 functions as an E3 ubiquitin ligase, facilitating the ubiquitination of target proteins, which regulates their degradation and activity. It is expressed in various tissues, including the brain, immune system, and gastrointestinal tract. LONRF2 has been linked to diseases such as Immunodeficiency 15B, a genetic disorder that leads to recurrent infections and autoimmune issues, and childhood-onset inflammatory bowel disease, which affects gastrointestinal health. Recent studies suggest that LONRF2 is crucial for maintaining protein homeostasis, especially in post-mitotic cells, and its deficiency may lead to neurological deficits, underscoring its importance in both immune regulation and neuroprotection.