抗人 IgM 磁珠
02AB00051
Human IgM is the largest and first antibody produced by the body in response to an initial exposure to an antigen. IgM is a pentameric structure that is highly effective at activating the complement system and agglutinating pathogens. IgM plays a crucial role in the body's early immune response, as it is the first antibody to appear after infection or vaccination.IgM has a low affinity for antigens but its pentameric structure allows it to bind multiple epitopes, resulting in high avidity and efficient pathogen neutralization.IgM is also involved in the clearance of apoptotic cells and cancer cells through its ability to bind the apoptosis inhibitor of macrophage (AIM) protein.Deficiencies or abnormalities in IgM production have been linked to various diseases, including immunodeficiencies, autoimmune disorders, and infectious diseases.For example, low levels of IgM have been associated with increased susceptibility to infections, while elevated IgM levels can indicate ongoing or recent infection. Understanding the structure and functions of IgM continues to provide insights into its role in health and disease.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- IGHM
- 蛋白别名
- immunoglobulin heavy constant mu; Human IgM
- UniProt
- P01871
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- Human IgM
- 蛋白名称
- immunoglobulin heavy constant mu
- 蛋白别名
- Immunoglobulin heavy constant mu; Ig mu chain C region; Ig mu chain C region BOT; Ig mu chain C region GAL; Ig mu chain C region OU
- 靶点基因名
- IGHM
- UniProt
- P01871
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
Human IgM is the largest and first antibody produced by the body in response to an initial exposure to an antigen. IgM is a pentameric structure that is highly effective at activating the complement system and agglutinating pathogens. IgM plays a crucial role in the body's early immune response, as it is the first antibody to appear after infection or vaccination.IgM has a low affinity for antigens but its pentameric structure allows it to bind multiple epitopes, resulting in high avidity and efficient pathogen neutralization.IgM is also involved in the clearance of apoptotic cells and cancer cells through its ability to bind the apoptosis inhibitor of macrophage (AIM) protein.Deficiencies or abnormalities in IgM production have been linked to various diseases, including immunodeficiencies, autoimmune disorders, and infectious diseases.For example, low levels of IgM have been associated with increased susceptibility to infections, while elevated IgM levels can indicate ongoing or recent infection. Understanding the structure and functions of IgM continues to provide insights into its role in health and disease.