抗人 IgG4 抗体对
01AB00187
IgG4 is the least common of the four human IgG subclasses, accounting for only 3-6% of total serum IgG. It has a unique structure compared to other IgG subclasses, with a flexible hinge region and a CH2 domain loop that can adopt different conformations. IgG4 is unable to significantly bind C1q and activate the classical complement pathway, giving it reduced potential for immune activation. It can also undergo Fab arm exchange, where the two heavy chains separate and recombine randomly, resulting in bispecific antibodies unable to form immune complexes. The function of IgG4 varies depending on the context, with potential roles in dampening inflammation, acting as an antigen sink, and driving IgG4-related diseases characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells.
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技术参数
- 靶点基因名
- IGHG4
- 蛋白别名
- immunoglobulin heavy constant gamma 4 (G4m marker); Human IgG4
- UniProt
- P01861
- 物种
- Human
产品详情
- 靶点名称
- Human IgG4
- 蛋白名称
- immunoglobulin heavy constant gamma 4 (G4m marker)
- 蛋白别名
- Immunoglobulin heavy constant gamma 4; Ig gamma-4 chain C region
- 靶点基因名
- IGHG4
- UniProt
- P01861
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
IgG4 is the least common of the four human IgG subclasses, accounting for only 3-6% of total serum IgG. It has a unique structure compared to other IgG subclasses, with a flexible hinge region and a CH2 domain loop that can adopt different conformations. IgG4 is unable to significantly bind C1q and activate the classical complement pathway, giving it reduced potential for immune activation. It can also undergo Fab arm exchange, where the two heavy chains separate and recombine randomly, resulting in bispecific antibodies unable to form immune complexes. The function of IgG4 varies depending on the context, with potential roles in dampening inflammation, acting as an antigen sink, and driving IgG4-related diseases characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells.