抗人 IgG2 抗体对
01AB00163
Human Immunoglobulin G2 (IgG2) is one of the four primary subclasses of IgG, which is the most abundant protein in human serum. IgG2 accounts for approximately 10–20% of total plasma protein. Compared to other IgG subclasses, IgG2 exhibits distinctive structural characteristics such as having a more rigid hinge region due to a higher number of inter-heavy chain disulfide bridges, specifically up to four additional ones. This rigidity limits the flexibility of the IgG2 molecule. Additionally, IgG2 lacks certain glycan residues present in the hinge region of IgG1, resulting in differences in effector functions like antigen binding, immune complex formation, complement activation, and interaction with Fc receptors.IgG2 plays a crucial role in the immune response, particularly in protection against bacterial infections involving capsules. However, individuals who exhibit a deficiency in IgG2 may experience increased susceptibility to diseases caused by encapsulated bacteria.
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技术参数
- 靶点基因名
- IGHG2
- 蛋白别名
- immunoglobulin heavy constant gamma 2 (G2m marker); Human IgG2
- UniProt
- P01859
- 物种
- Human
产品详情
- 靶点名称
- Human IgG2
- 蛋白名称
- immunoglobulin heavy constant gamma 2 (G2m marker)
- 蛋白别名
- Immunoglobulin heavy constant gamma 2; Ig gamma-2 chain C region; Ig gamma-2 chain C region DOT; Ig gamma-2 chain C region TIL; Ig gamma-2 chain C region ZIE
- 靶点基因名
- IGHG2
- UniProt
- P01859
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Human Immunoglobulin G2 (IgG2) is one of the four primary subclasses of IgG, which is the most abundant protein in human serum. IgG2 accounts for approximately 10–20% of total plasma protein. Compared to other IgG subclasses, IgG2 exhibits distinctive structural characteristics such as having a more rigid hinge region due to a higher number of inter-heavy chain disulfide bridges, specifically up to four additional ones. This rigidity limits the flexibility of the IgG2 molecule. Additionally, IgG2 lacks certain glycan residues present in the hinge region of IgG1, resulting in differences in effector functions like antigen binding, immune complex formation, complement activation, and interaction with Fc receptors.IgG2 plays a crucial role in the immune response, particularly in protection against bacterial infections involving capsules. However, individuals who exhibit a deficiency in IgG2 may experience increased susceptibility to diseases caused by encapsulated bacteria.