抗人 IgG1 抗体对
01AB00162
Human IgG1 is the most abundant subclass of IgG antibodies, representing 60-70% of total IgG in human serum. IgG1 has a flexible structure with a longer hinge region compared to other IgG subclasses, allowing for greater mobility of the Fab fragments relative to the Fc region. This flexibility affects IgG1's ability to bind and activate the classical complement pathway through C1q, as well as its binding to Fc receptors (FcγR) on phagocytic cells to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis. Deficiencies or abnormalities in IgG1 levels or function have been associated with various disease states. IgG1 deficiency is often linked to hypogammaglobulinemia, as IgG1 makes up the majority of total IgG, and low IgG1 levels can lead to increased susceptibility to viral infections. Conversely, excessive or dysregulated IgG1 responses have been implicated in autoimmune diseases and allergic disorders.
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技术参数
- 靶点基因名
- IGHG1
- 蛋白别名
- immunoglobulin heavy constant gamma 1 (G1m marker); Human IgG1
- UniProt
- P01857
- 物种
- Human
产品详情
- 靶点名称
- Human IgG1
- 蛋白名称
- immunoglobulin heavy constant gamma 1 (G1m marker)
- 蛋白别名
- Immunoglobulin heavy constant gamma 1; Ig gamma-1 chain C region; Ig gamma-1 chain C region EU; Ig gamma-1 chain C region KOL; Ig gamma-1 chain C region NIE
- 靶点基因名
- IGHG1
- UniProt
- P01857
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Human IgG1 is the most abundant subclass of IgG antibodies, representing 60-70% of total IgG in human serum. IgG1 has a flexible structure with a longer hinge region compared to other IgG subclasses, allowing for greater mobility of the Fab fragments relative to the Fc region. This flexibility affects IgG1's ability to bind and activate the classical complement pathway through C1q, as well as its binding to Fc receptors (FcγR) on phagocytic cells to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis. Deficiencies or abnormalities in IgG1 levels or function have been associated with various disease states. IgG1 deficiency is often linked to hypogammaglobulinemia, as IgG1 makes up the majority of total IgG, and low IgG1 levels can lead to increased susceptibility to viral infections. Conversely, excessive or dysregulated IgG1 responses have been implicated in autoimmune diseases and allergic disorders.