抗人 IgA 抗体对
01AB00218
Human IgA is the most abundant antibody produced in the human body, with important roles in immune defense and regulation. There are two main subclasses, IgA1 and IgA2, which differ in their structure and effector functions. Serum IgA can have both pro-inflammatory and anti-inflammatory effects. IgA2 is more effective than IgA1 at inducing neutrophil extracellular trap formation and cytokine production in myeloid cells. Abnormal IgA levels, either too high or too low, have been associated with various diseases, including IgA nephropathy, autoimmune disorders like rheumatoid arthritis, and immunodeficiencies like selective IgA deficiency. The ratio of IgA1 to IgA2 has also been linked to disease severity in rheumatoid arthritis. Overall, IgA plays a critical role in regulating immune responses and maintaining homeostasis, and dysregulation of IgA can contribute to the development of inflammatory and autoimmune conditions.
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技术参数
- 靶点基因名
- IGHA2,IGHA1/IGHA2
- 蛋白别名
- Immunoglobulin heavy constant alpha 1/lmmunoglobulin |heavy constant alpha 2; Human IgA
- UniProt
- P01876/P01877
- 物种
- Human
产品详情
- 靶点名称
- Human IgA
- 蛋白名称
- Immunoglobulin heavy constant alpha 1/lmmunoglobulin |heavy constant alpha 2
- 靶点基因名
- IGHA2,IGHA1/IGHA2
- UniProt
- P01876/P01877
- 来源物种
- /
背景介绍
Human IgA is the most abundant antibody produced in the human body, with important roles in immune defense and regulation. There are two main subclasses, IgA1 and IgA2, which differ in their structure and effector functions. Serum IgA can have both pro-inflammatory and anti-inflammatory effects. IgA2 is more effective than IgA1 at inducing neutrophil extracellular trap formation and cytokine production in myeloid cells. Abnormal IgA levels, either too high or too low, have been associated with various diseases, including IgA nephropathy, autoimmune disorders like rheumatoid arthritis, and immunodeficiencies like selective IgA deficiency. The ratio of IgA1 to IgA2 has also been linked to disease severity in rheumatoid arthritis. Overall, IgA plays a critical role in regulating immune responses and maintaining homeostasis, and dysregulation of IgA can contribute to the development of inflammatory and autoimmune conditions.