抗 HLA-C 磁珠
02AB00082
The Major Histocompatibility Complex, class I, C (HLA-C) protein is a cell membrane glycoprotein that plays an essential role in immune response by presenting peptides to cytotoxic T lymphocytes and interacting with natural killer (NK) cells through specific receptors like KIR. It consists of a heavy chain and a light beta-2 microglobulin chain, with structural regions encoded by eight exons. HLA-C expression is lower than related molecules HLA-A and HLA-B, regulated by polymorphisms and epigenetics, and its main function is to mediate immune recognition, including antiviral and cancer defenses. HLA-C's interaction with NK cells is crucial for the elimination of harmful cells, which also impacts organ transplant rejection and autoimmune disease modulation. Pathologically, variations in HLA-C are linked to diseases such as psoriasis, alopecia areata, preeclampsia, and certain cancers (e.g., nasopharyngeal, cervical, acute myeloid leukemia). The HLA-C/KIR signaling pathway modulates immune tolerance and cytotoxicity, influencing disease susceptibility and treatment outcomes.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 宿主
- Mouse
- 靶点基因名
- HLA-C
- 基因别名
- HLAC
- 蛋白别名
- major histocompatibility complex, class I, C; HLA-C(alpha-2 specific)
- UniProt
- P10321
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- HLA-C(alpha-2 specific)
- 蛋白名称
- major histocompatibility complex, class I, C
- 蛋白别名
- HLA class I histocompatibility antigen; C alpha chain; HLA-C; HLA-Cw; Human leukocyte antigen C
- 靶点基因名
- HLA-C
- 基因别名
- HLAC
- UniProt
- P10321
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
LEAARAAEQL
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
The Major Histocompatibility Complex, class I, C (HLA-C) protein is a cell membrane glycoprotein that plays an essential role in immune response by presenting peptides to cytotoxic T lymphocytes and interacting with natural killer (NK) cells through specific receptors like KIR. It consists of a heavy chain and a light beta-2 microglobulin chain, with structural regions encoded by eight exons. HLA-C expression is lower than related molecules HLA-A and HLA-B, regulated by polymorphisms and epigenetics, and its main function is to mediate immune recognition, including antiviral and cancer defenses. HLA-C's interaction with NK cells is crucial for the elimination of harmful cells, which also impacts organ transplant rejection and autoimmune disease modulation. Pathologically, variations in HLA-C are linked to diseases such as psoriasis, alopecia areata, preeclampsia, and certain cancers (e.g., nasopharyngeal, cervical, acute myeloid leukemia). The HLA-C/KIR signaling pathway modulates immune tolerance and cytotoxicity, influencing disease susceptibility and treatment outcomes.