抗 HERC5 磁珠
02AB00084
E3 ISG15--protein ligase HERC5 (HERC5) is a member of the HERC family of ubiquitin ligases and functions as an interferon-induced E3 protein ligase that mediates ISGylation of target proteins. It is a multidomain protein with a HECT domain and five RCC1 repeats. HERC5 localizes to the cytoplasm and perinuclear region and acts as a modulator of the antiviral immune response. It broadly modifies newly synthesized proteins in a cotranslational manner, with viral proteins being primary targets in interferon-stimulated cells. HERC5-mediated ISGylation has been shown to interfere with the function of key viral structural proteins, such as ebolavirus VP40 or HIV-1 GAG, and attenuate the virulence of influenza A virus by ISGylating the NS1 protein. Dysregulation of HERC5 has been associated with influenza. Its ability to promote the production of cytokines that facilitate bacterial clearance highlights its importance in the immune response beyond viral infections.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- HERC5
- 基因别名
- CEB1; CEBP1
- 蛋白别名
- HECT and RLD domain containing E3 ubiquitin protein ligase 5; HERC5
- UniProt
- Q9UII4
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- HERC5
- 蛋白名称
- HECT and RLD domain containing E3 ubiquitin protein ligase 5
- 蛋白别名
- E3 ISG15--protein ligase HERC5; Cyclin-E-binding protein 1; HECT domain and RCC1-like domain-containing protein 5
- 靶点基因名
- HERC5
- 基因别名
- CEB1; CEBP1
- UniProt
- Q9UII4
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
RESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNN
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
E3 ISG15--protein ligase HERC5 (HERC5) is a member of the HERC family of ubiquitin ligases and functions as an interferon-induced E3 protein ligase that mediates ISGylation of target proteins. It is a multidomain protein with a HECT domain and five RCC1 repeats. HERC5 localizes to the cytoplasm and perinuclear region and acts as a modulator of the antiviral immune response. It broadly modifies newly synthesized proteins in a cotranslational manner, with viral proteins being primary targets in interferon-stimulated cells. HERC5-mediated ISGylation has been shown to interfere with the function of key viral structural proteins, such as ebolavirus VP40 or HIV-1 GAG, and attenuate the virulence of influenza A virus by ISGylating the NS1 protein. Dysregulation of HERC5 has been associated with influenza. Its ability to promote the production of cytokines that facilitate bacterial clearance highlights its importance in the immune response beyond viral infections.