抗 DTX3L 磁珠
02AB00077
E3 ubiquitin-protein ligase DTX3L (DTX3L) is a multi-domain protein that plays a critical role in the ubiquitination process, which regulates protein stability and cellular signaling. DTX3L is characterized by its RING domain, essential for its ligase activity, and interacts with PARP9 to facilitate DNA damage repair and antiviral responses. DTX3L can ubiquitinate single-stranded nucleic acids, suggesting a novel role in regulating nucleic acid metabolism and response to DNA damage. It has been implicated in various cancers, including lymphomas, gliomas, and melanomas, where its overexpression is associated with tumor progression and chemoresistance. DTX3L promotes cell adhesion, proliferation, and migration, contributing to the aggressive behavior of tumors. Additionally, dysregulation of DTX3L has been linked to autoimmune diseases, further emphasizing its relevance in pathological conditions.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- DTX3L
- 基因别名
- BBAP
- 蛋白别名
- deltex E3 ubiquitin ligase 3L; DTX3L
- UniProt
- Q8TDB6
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- DTX3L
- 蛋白名称
- deltex E3 ubiquitin ligase 3L
- 蛋白别名
- E3 ubiquitin-protein ligase DTX3L; B-lymphoma- and BAL-associated protein; Protein deltex-3-like; RING-type E3 ubiquitin transferase DTX3L; Rhysin-2; Rhysin2
- 靶点基因名
- DTX3L
- 基因别名
- BBAP
- UniProt
- Q8TDB6
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
RVRRKLESYFQSSKSSGGGECTVSTQEHEAPGTFRVEFSERAAKERVLKKGEHQILVDEKPVPIFLVPTENSIKKNTRPQISSLTQSQAETPSGDMHQHE
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
E3 ubiquitin-protein ligase DTX3L (DTX3L) is a multi-domain protein that plays a critical role in the ubiquitination process, which regulates protein stability and cellular signaling. DTX3L is characterized by its RING domain, essential for its ligase activity, and interacts with PARP9 to facilitate DNA damage repair and antiviral responses. DTX3L can ubiquitinate single-stranded nucleic acids, suggesting a novel role in regulating nucleic acid metabolism and response to DNA damage. It has been implicated in various cancers, including lymphomas, gliomas, and melanomas, where its overexpression is associated with tumor progression and chemoresistance. DTX3L promotes cell adhesion, proliferation, and migration, contributing to the aggressive behavior of tumors. Additionally, dysregulation of DTX3L has been linked to autoimmune diseases, further emphasizing its relevance in pathological conditions.