抗 DTX2 磁珠
02AB00121
Deltex 2 (DTX2) is a member of the Deltex family of E3 ubiquitin ligases, which play critical roles in various cellular processes, including signal transduction, growth, and apoptosis. DTX2 is particularly noted for its involvement in the regulation of Notch signaling, a pathway essential for cell fate determination and tissue homeostasis. Dysregulation of DTX2 has been implicated in the development of several cancers, highlighting its potential oncogenic role. Recent studies suggest that DTX2, along with other Deltex proteins, may influence tumor progression through mechanisms that involve the ubiquitination of target proteins and interactions with other signaling pathways. Furthermore, the complex interplay between DTX2 and DNA damage response mechanisms underscores its significance in both normal cellular functions and pathological conditions, making it a potential target for therapeutic interventions in cancer and other diseases.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- DTX2
- 基因别名
- KIAA1528; RNF58
- 蛋白别名
- deltex E3 ubiquitin ligase 2; DTX2
- UniProt
- Q86UW9
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- DTX2
- 蛋白名称
- deltex E3 ubiquitin ligase 2
- 蛋白别名
- Probable E3 ubiquitin-protein ligase DTX2; Protein deltex-2; Deltex2; hDTX2; RING finger protein 58; RING-type E3 ubiquitin transferase DTX2
- 靶点基因名
- DTX2
- 基因别名
- KIAA1528; RNF58
- UniProt
- Q86UW9
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Oligoclonal
- 亚型
- IgG
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
Deltex 2 (DTX2) is a member of the Deltex family of E3 ubiquitin ligases, which play critical roles in various cellular processes, including signal transduction, growth, and apoptosis. DTX2 is particularly noted for its involvement in the regulation of Notch signaling, a pathway essential for cell fate determination and tissue homeostasis. Dysregulation of DTX2 has been implicated in the development of several cancers, highlighting its potential oncogenic role. Recent studies suggest that DTX2, along with other Deltex proteins, may influence tumor progression through mechanisms that involve the ubiquitination of target proteins and interactions with other signaling pathways. Furthermore, the complex interplay between DTX2 and DNA damage response mechanisms underscores its significance in both normal cellular functions and pathological conditions, making it a potential target for therapeutic interventions in cancer and other diseases.