抗 CUL9 磁珠
02AB00071
Cullin-9 (CUL9) is a member of the cullin family of proteins, which are essential components of cullin-RING ligases (CRLs) that function as E3 ubiquitin ligases, facilitating the ubiquitination and subsequent degradation of target proteins. CUL9 is unique due to its additional RING domain at the C-terminus, which enhances its functional versatility. CUL9 plays a critical role in maintaining genome integrity by regulating the stability of key proteins involved in cell cycle progression and apoptosis, such as survivin. In scientific experiments, CUL9 is often studied for its interactions with various protein complexes, including the anaphase-promoting complex/cyclosome (APC/C), which is crucial for cell cycle regulation. Techniques such as immunoprecipitation and mass spectrometry have been employed to identify CUL9 substrates and interacting partners, revealing its involvement in diverse cellular processes. Additionally, CUL9 knockout models have demonstrated its importance in tumor suppression, as these models develop spontaneous tumors, underscoring its role in cellular homeostasis.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- CUL9
- 基因别名
- H7AP1; KIAA0708; PARC
- 蛋白别名
- cullin 9; CUL9
- UniProt
- Q8IWT3
- 物种
- Human, Mouse
- 应用
- IP
产品详情
- 靶点名称
- CUL9
- 蛋白名称
- cullin 9
- 蛋白别名
- Cullin-9; CUL-9; UbcH7-associated protein 1; p53-associated parkin-like cytoplasmic protein
- 靶点基因名
- CUL9
- 基因别名
- H7AP1; KIAA0708; PARC
- UniProt
- Q8IWT3
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human, Mouse
- 克隆性
- Monoclonal
- 亚型
- IgG1
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
SSSTSRNHSCTPDPEEESKSEASFSEEETESLKAKAEAPKTEAEPTKTRTETPMAQSDSQLFNQLLVTEGMTLPTEMKEAASEMARALRGPGPRSSLDQHVAAVVATVQISSLDTNLQLSGLSALSQAVE
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
Cullin-9 (CUL9) is a member of the cullin family of proteins, which are essential components of cullin-RING ligases (CRLs) that function as E3 ubiquitin ligases, facilitating the ubiquitination and subsequent degradation of target proteins. CUL9 is unique due to its additional RING domain at the C-terminus, which enhances its functional versatility. CUL9 plays a critical role in maintaining genome integrity by regulating the stability of key proteins involved in cell cycle progression and apoptosis, such as survivin. In scientific experiments, CUL9 is often studied for its interactions with various protein complexes, including the anaphase-promoting complex/cyclosome (APC/C), which is crucial for cell cycle regulation. Techniques such as immunoprecipitation and mass spectrometry have been employed to identify CUL9 substrates and interacting partners, revealing its involvement in diverse cellular processes. Additionally, CUL9 knockout models have demonstrated its importance in tumor suppression, as these models develop spontaneous tumors, underscoring its role in cellular homeostasis.