抗丁烯酰赖氨酸磁珠
02AB00112
Lysine crotonylation is a recently discovered post-translational modification that differs structurally and functionally from lysine acetylation. This modification involves the addition of a crotonyl group to the lysine residue of proteins, impacting various biological processes. Crotonylation has been identified on both histone and non-histone proteins, playing critical roles in chromatin remodeling, metabolism, cell cycle regulation, and cellular organization. It is dynamically regulated by specific enzymes known as "writers," "erasers," and "readers," which add, remove, and recognize the crotonyl group, respectively. Functionally, lysine crotonylation is implicated in gene transcription, spermatogenesis, telomere maintenance, and the regulation of diseases such as cancer and depression. The modification's unique structure, featuring a four-carbon crotonyl group with a C–C π bond, enhances its specificity and functional outcomes compared to other lysine acylations.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 蛋白别名
- Crotonyl Lysine
- 应用
- IP
产品详情
- 靶点名称
- Crotonyl Lysine
- 来源物种
- /
- 宿主物种
- Mouse
- 克隆性
- Oligoclonal
- 亚型
- IgG
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
Lysine crotonylation is a recently discovered post-translational modification that differs structurally and functionally from lysine acetylation. This modification involves the addition of a crotonyl group to the lysine residue of proteins, impacting various biological processes. Crotonylation has been identified on both histone and non-histone proteins, playing critical roles in chromatin remodeling, metabolism, cell cycle regulation, and cellular organization. It is dynamically regulated by specific enzymes known as "writers," "erasers," and "readers," which add, remove, and recognize the crotonyl group, respectively. Functionally, lysine crotonylation is implicated in gene transcription, spermatogenesis, telomere maintenance, and the regulation of diseases such as cancer and depression. The modification's unique structure, featuring a four-carbon crotonyl group with a C–C π bond, enhances its specificity and functional outcomes compared to other lysine acylations.