抗 BRAP 磁珠
02AB00139
BRCA1-associated protein (BRAP) is a multifunctional protein that interacts with the tumor suppressor BRCA1 and plays crucial roles in various cellular processes, including DNA repair, cell cycle regulation, and transcription control. BRAP functions as an E3 ubiquitin ligase, mediating the ubiquitination and subsequent degradation of target proteins, thereby modulating their activity and cellular localization. Dysregulation or mutations in BRAP have been linked to an increased risk of several cancers, particularly breast and ovarian cancer, where it may contribute to tumorigenesis by impairing DNA damage response and repair pathways. Additionally, BRAP has been implicated in other diseases, such as cardiovascular disorders and neurodegenerative diseases, highlighting its importance in maintaining cellular homeostasis.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- BRAP
- 基因别名
- RNF52
- 蛋白别名
- BRCA1 associated protein; BRAP
- UniProt
- Q7Z569
- 物种
- Human
- 应用
- IP
产品详情
- 靶点名称
- BRAP
- 蛋白名称
- BRCA1 associated protein
- 蛋白别名
- BRCA1-associated protein; BRAP2; Impedes mitogenic signal propagation; IMP; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; Renal carcinoma antigen NY-REN-63
- 靶点基因名
- BRAP
- 基因别名
- RNF52
- UniProt
- Q7Z569
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human
- 克隆性
- Monoclonal
- 亚型
- IgG2a
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
MKTKFKETIEKCDNLEHKLNDLLKEKQSVERKCTQLNTKVAKLTNELKEEQEMNKCLRANQVLLQNKLKEEERVLKETCDQKDLQITEIQEQLRDVMFYLETQQKINHLPAETRQEIQEGQINIAMASASSPASSGGSGKLPSRKGRSKR
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
BRCA1-associated protein (BRAP) is a multifunctional protein that interacts with the tumor suppressor BRCA1 and plays crucial roles in various cellular processes, including DNA repair, cell cycle regulation, and transcription control. BRAP functions as an E3 ubiquitin ligase, mediating the ubiquitination and subsequent degradation of target proteins, thereby modulating their activity and cellular localization. Dysregulation or mutations in BRAP have been linked to an increased risk of several cancers, particularly breast and ovarian cancer, where it may contribute to tumorigenesis by impairing DNA damage response and repair pathways. Additionally, BRAP has been implicated in other diseases, such as cardiovascular disorders and neurodegenerative diseases, highlighting its importance in maintaining cellular homeostasis.