抗 AREL1 磁珠
02AB00106
The AREL1 gene encodes the apoptosis-resistant E3 ubiquitin protein ligase 1, a protein that plays a crucial role in regulating apoptosis, protein ubiquitination, and cellular processes. It is a member of the HECT-type E3 ubiquitin transferase family and is involved in the ubiquitination of various proteins, including SEPTIN4, DIABLO/SMAC, and HTRA2. The AREL1 protein is also known to modulate pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome. Mutations in the AREL1 gene have been associated with endometrial cancer and colorectal cancer, as well as hereditary nonpolyposis type 7. The gene is expressed in various tissues, including the brain, liver, and immune cells, and is involved in the regulation of multiple cellular processes.
| 规格 | 起售价 |
|---|---|
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技术参数
- 宿主
- Mouse
- 靶点基因名
- AREL1
- 基因别名
- KIAA0317
- 蛋白别名
- apoptosis resistant E3 ubiquitin protein ligase 1; AREL1
- UniProt
- O15033
- 物种
- Human, Rat
- 应用
- IP
产品详情
- 靶点名称
- AREL1
- 蛋白名称
- apoptosis resistant E3 ubiquitin protein ligase 1
- 蛋白别名
- Apoptosis-resistant E3 ubiquitin protein ligase 1; Apoptosis-resistant HECT-type E3 ubiquitin transferase 1
- 靶点基因名
- AREL1
- 基因别名
- KIAA0317
- UniProt
- O15033
- 来源物种
- Homo sapiens (Human)
- 宿主物种
- Mouse
- 物种反应性
- Human, Rat
- 克隆性
- Monoclonal
- 亚型
- IgG2b
- 配方
- Supplied as solution in phosphate buffered saline containing 0.1% BSA and 0.02% sodium azide
- 剂型
- Subject to solid-liquid separation upon standing; Mix thoroughly to ensure a consistent, homogeneous
免疫原核心序列
FDIIVLSEDEKNIVERNVSTSGVSIYFEAYLYNATNCSSTPWHLPPMHMTSSQRRPSTAVDEEDEDSPSECHTPEKVKKP
| 应用 | 推荐稀释比 | 备注 |
|---|---|---|
| IP | — | 50-100 μL/200 μg cell lysate |
背景介绍
The AREL1 gene encodes the apoptosis-resistant E3 ubiquitin protein ligase 1, a protein that plays a crucial role in regulating apoptosis, protein ubiquitination, and cellular processes. It is a member of the HECT-type E3 ubiquitin transferase family and is involved in the ubiquitination of various proteins, including SEPTIN4, DIABLO/SMAC, and HTRA2. The AREL1 protein is also known to modulate pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome. Mutations in the AREL1 gene have been associated with endometrial cancer and colorectal cancer, as well as hereditary nonpolyposis type 7. The gene is expressed in various tissues, including the brain, liver, and immune cells, and is involved in the regulation of multiple cellular processes.